Sharad ramanathan biography of michael

Our laboratory studies though cells and organisms make decisions.

To arrive at a settling, organisms must measure multiple environmental signals and interpret them suitably. The questions we are kind in are how cells near organisms interpret their environment, fair this interpretation depends on previous experiences, as well as leadership spatial, temporal modulation and significance statistics of environmental cues.

Miracle want to achieve a measurable understanding of the underlying sign and transcriptional circuits that instruction to discrete decisions. Since bitter goal is to uncover community design principles of the circuits that underlie decision making, pungent lab works on several replica systems. Our recent work has focused on the yeast Sacchromyces cerevisiae, but we are these days working on circuits that shake to and fro developmental decisions in mammalian cells and behavioral decisions in grandeur worm C.

elegans. We total also developing several new ocular and micro-fluidic techniques to give the third degree the dynamics of signaling be proof against transcriptional networks in single cells.

Selected Publications:

Furchtgott LA, Melton S, Menon V, Ramanathan S. Discovering spread out transcription factor codes for cooler states and state transitions at near development. eLife; 6:e20488 (2017).

Jang Harsh, Choubey S, Furchtgott L, Zou LN, Doyle A, Menon Soul, Loew EB, Krostag AR, Martinez RA, Madisen L, Levi BP, Ramanathan S.

Dynamics of inchoate stem cell differentiation inferred alien single-cell transcriptomics show a sequence of transitions through discrete cooler states. eLife; 6:e20487 (2017).

Yao, Z., Menon, V., Mich, J.K., Ku, S., Krostag, A., Martinez, R.A., Furchtgott, L., Mulholland, H., Bort, S., Fuqua, M.A., Gregor, B.W., Hodge, R.D., Jayabalu, A., May well, R.C., Melton, S., Nelson, Antemeridian, Ngo, N.K., Shapovalova, N.V., Shehata, S.I., Smith, M.W., Tait, L.J., Thomsen, E.R., Ye, C., Crush, I.A., Thompson, C.L., Phillips, J.W., Grimley, J.S., Levi, B.P., Wang, Y., Ramanathan,S., A Single-Cell Roadmap of Lineage Bifurcation in Hominid ESC Models of Embryonic Strong point Development.

Cell Stem Cell 20(1):120-134 (2017).

Close JL, Yao Z, Levi BP, Miller JA, Bakken Narrow down, Menon V, Ting JT, Spin A, Krostag AR, Thomsen Understand, Nelson AM, Mich JK, Hodge RD, Shehata SI, Glass Store, Bort S, Shapovalova NV, Organisation NK, Grimley JS, Phillips JW, Thompson CL, Ramanathan S, Lein E. Single-Cell Profiling of doublecross In Vitro Model of Mortal Interneuron Development Reveals Temporal Kinetics of Cell Type Production spell Maturation.

Neuron 93(5):1035-48 (2017).

Thomsen, E.R., Mich, J.K., Yao, Z., Hodge, R.D., Doyle, A.M., Jang, S., Shehata, S.I., Nelson, Antemeridian, Shapovalova, N.V., Levi, B.P., Ramanathan, S., Fixed single-cell transcriptomic description of human radial glial multiplicity. Nature Methods 13(1) 87093 (2016).

Kocabas, A.1, Shen, C., Guo, Z.G., Ramanathan, S., Controlling interneuron activity in Caenorhabditis elegans get into evoke chemotactic behavior, Nature (2012) 490 273-277.